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目的 探讨二甲双胍对高脂蛋白血清载脂蛋白B(ApoB)的影响。方法 Ⅱ型糖尿病 (DM )伴高脂蛋白血症的 5 6例患者随机分为A、B两组 ,36例非DM伴高脂蛋白血症患者为C组 ,A为对照组 ,B、C为治疗组 ,治疗组服用二甲双胍 ,对照组服用格列吡嗪。结果 ApoB在 8周及 12周后治疗组较对照组明显降低 (P <0 0 1)。结论 二甲双胍除了能降低Ⅱ型DM患者血糖及改善胰岛素敏感性外 ,还有助于纠正Ⅱ型DM伴高脂血症及非DM而高血脂者的代谢异常 ,有明显降低血清ApoB的作用
Objective To investigate the effect of metformin on serum apolipoprotein B (ApoB) in hyperlipidemia. Methods Fifty-six patients with type 2 diabetes mellitus (DM) accompanied by hyperlipoproteinemia were randomly divided into two groups: A, B, 36 cases of non-DM with hyperlipoproteinemia as C group, A as control group, B, C For the treatment group, the treatment group taking metformin, the control group taking glipizide. Results ApoB was significantly lower in the treatment group than in the control group at 8 and 12 weeks (P <0.01). Conclusion Metformin can not only reduce the blood sugar and improve the insulin sensitivity of type Ⅱ DM patients, but also help to correct the type Ⅱ DM with hyperlipidemia and non-DM and hyperlipidemia metabolic abnormalities, significantly reduce the role of serum ApoB