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为了阐明中药南鹤虱的化学成分,采用各种柱色谱及制备液相色谱进行分离纯化,从南鹤虱中分离得到9个愈创木烷型倍半萜成分,经理化性质和波谱数据确定其结构分别为11-羟基-8β-当归酰氧基-4-愈创木烯-3-酮(1)、11-乙酰氧基-4-愈创木烯-3-酮(2)、11-乙酰氧基-8β-异丁酰氧基-4-愈创木烯-3-酮(3)、11-乙酰氧基-8β-丙酰氧基-4-愈创木烯-3-酮(4)、11-羟基-4-愈创木烯-3-酮(5)、1β-羟基-11-乙酰氧基-8β-当归酰氧基-4-愈创木烯-3-酮(6)、11-乙酰氧基-8β-当归酰氧基-4-愈创木烯-3-酮(7)、8β-羟基-11-乙酰氧基-4-愈创木烯-3-酮(8)和8β,11-二羟基-4-愈创木烯-3-酮(9)。其中化合物1为新化合物,化合物5为新的天然产物,化合物2~4为首次从该属植物中分离得到的。
In order to elucidate the chemical constituents of the Chinese louse louse, nine kinds of guaiacane sesquiterpenoids were isolated and purified by column chromatography and preparative liquid chromatography (HPLC), and their chemical properties and spectral data were determined Their structures are 11-hydroxy-8β-angeloyloxy-4-guauryn-3-one (1), 11-acetoxy- -acetoxy-8β-isobutyryloxy-4-gua-ene-3-one (3), 11-acetoxy-8β-propionyloxy- (5), 1β-hydroxy-11-acetoxy-8β-angeloyloxy-4-guauryn-3-one (4) 6), 11-acetoxy-8β-angeloyloxy-4-guauryn-3-one (7), 8β-hydroxy-11-acetoxy- (8) and 8β, 11-dihydroxy-4-guauryn-3-one (9). Among them, compound 1 was a new compound, compound 5 was a new natural product, and compounds 2 ~ 4 were isolated from this genus for the first time.