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作者通过动物实验研究喉CO_2激光照射后伤口愈合的机制。用8只猎狗,全麻下用10W功率的CO_2激光,气化每只狗的一侧声带上皮并切割会厌的部分上皮和软骨。在处理后即刻及第2、4、7、10、14、28、42天各处死一只,切取其喉,对会厌、声带进行检查。肉眼观察:开始其创面呈浅黄色并附有一些碳化碎片,一天后表面有苍黄色凝块形成,持续至4周后上皮完全重新生长、肿胀很轻,伤口周围有红斑,无肉芽组织,伤口全部愈合。6周后,无明显瘢痕收缩,亦无畸形遗留。组织学检查:声带和会厌所见基本相似。激光作用附近的组织损伤区范围较小,覆盖于创面的纤维素凝块中含多形核白细胞,4
The author studied the mechanism of wound healing after throat CO_2 laser irradiation through animal experiments. Eight dogs were anesthetized with CO 2 laser at 10 W power to vaporize the vocal folds of one side of each dog and to cut off part of the epidermis and cartilage of the epiglottis. Immediately after treatment and on the 2nd, 4th, 7th, 10th, 14th, 28th and 42nd days, each one killed one, cut its larynx and examined epiglottis and vocal cords. Macroscopical observation: At the beginning of its wound was pale yellow with some carbonized debris, a day after the formation of pale yellow clot formation, until 4 weeks after the epithelial complete regrowth, swelling is very light, erythema around the wound, no granulation tissue, wounds All healed. After 6 weeks, no significant scar contraction, no deformity left. Histological examination: Vocal cord and epiglottis seen similar. The tissue damage zone near the laser action is smaller in size, covering the wound with cellulose polymorphonuclear leukocytes, 4