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本文报道T淋巴细胞系对γ干扰素(IFN-γ)的反应。作者用IFN-α/β和其他细胞系作对比,发现T淋巴细胞对IFN-γ的反应和对IFN-α/β的反应有许多不同。IFN-γ对T细胞系和非T细胞系的作用也不同。首先,不同于IFN-α/β,IFN-γ对T细胞系不能诱生抗病毒状态和激活2′-5′寡腺苷酸(2′-5′A)合成酶;其次,T淋巴细胞对IFN-γ的抗病毒作用缺乏敏感性并非由于特异性膜受体缺如,因为通过~(125)I标记的IFN-γ对T细胞和其他细胞的结合实验表明,实验中所用的T细胞系都具有IFN-γ特异性受体,其结
This article reports the response of T lymphocyte lines to interferon gamma (IFN-γ). The authors compared IFN-α / β with other cell lines and found that T lymphocytes respond differently to IFN-γ and respond differently to IFN-α / β. The effect of IFN-γ on T-cell lines and non-T-cell lines is also different. First, unlike IFN-α / β, IFN-γ fails to induce antiviral status on T-cell lines and activates 2’-5 ’oligoadenylate (2’-5’A) synthetase. Second, T lymphocytes The lack of sensitivity to the antiviral effect of IFN-γ was not due to absence of specific membrane receptors, as the binding of T-cells to other cells by ~ (125) I-labeled IFN-γ demonstrated that the T cells used in the experiment Department have IFN-γ-specific receptor, the conclusion