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目的:初步探讨血清脂联素(ADPN)、高敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)在急性脑梗死(acute cerebral infarction,ACI)中的动态变化,并测定其与ACI病情严重程度之间的关系。方法:随机选取于我院就诊的65例ACI住院患者(ACI组)及30例健康成人(对照组),均于发病后24h内入院,分别在入院时、第1周末、第2个月末抽取空腹静脉血,采取免疫增强比浊法测定hs-CRP,采取酶联免疫吸附剂测定(ELISA)法动态检测血清ADPN、IL-6的水平,采取改良爱丁堡-斯堪的纳维亚评分(MESSS)评价ACI的严重程度,采用方差分析与Pearson相关分析,行SPSS 18.0统计软件包处理结果。结果:ACI组hs-CRP和IL-6水平在发病后入院时、第1周末、第2个月末均高于对照组(P<0.05),ADPN在入院时、第1周末明显降低(P<0.01),而第2个月末呈升高趋势,但与对照组比较差异无统计学意义。MESSS在ACI入院时、第1周末、第2个月末时分别为(17.8±10.4)、(14.2±10.3)和(10.7±9.9)。MESSS与hs-CRP水平有统计学意义(r=0.228,P=0.015),但与IL-6、ADPN水平之间差异无统计学意义(r=-0.058,P=0.659;r=0.007,P=0.213)。结论:血清hs-CRP、IL-6水平在ACI发病后升高,ADPN部分时间段降低,说明炎性因子可能参与了ACI发生、发展的过程。
Objective: To investigate the dynamic changes of serum adiponectin (ADPN), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in acute cerebral infarction (ACI) Its relationship with the severity of ACI. Methods: Sixty-five ACI inpatients (ACI group) and 30 healthy adults (control group) were randomly selected in our hospital and were admitted to hospital within 24 hours after onset. They were admitted on admission, at the end of the first weekend and at the end of the second month Fasting venous blood was collected. The serum hs-CRP level was measured by ELISA. Serum levels of ADPN and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA), and the scores of modified Edinburgh-Scandinavian score (MESSS ) To assess the severity of ACI, analysis of variance and Pearson correlation analysis, line SPSS 18.0 statistical package processing results. Results: The levels of hs-CRP and IL-6 in ACI group were significantly higher than those in control group at the end of the first week and the end of the second month after admission (P <0.05). ADPN was significantly lower at the first weekend after admission (P < 0.01), while the second month showed a rising trend, but the difference was not statistically significant compared with the control group. MESSS at admission to ACI were (17.8 ± 10.4), (14.2 ± 10.3) and (10.7 ± 9.9) at the end of the first weekend and the end of the second month respectively. The levels of MESSS and hs-CRP were statistically significant (r = 0.228, P = 0.015), but there was no significant difference with IL-6 and ADPN levels (r = -0.058, P = 0.659; = 0.213). CONCLUSION: Serum levels of hs-CRP and IL-6 increase after ACI onset and ADPN decrease at some time, indicating that inflammatory cytokines may be involved in the occurrence and development of ACI.