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细胞凋亡被公认为是正常组织生长调节的一种重要机制,与增殖相对。凋亡细胞及时被清除,一方面可以防止胞内有毒物质的释放,避免组织炎症的发生;另一方面也可以阻止核物质的释放,防止自身免疫性疾病如红斑狼疮等的发生。凋亡细胞主要被吞噬细胞吞噬清除,接触和识别是吞噬发生的前提,吞噬细胞对凋亡细胞的识别有多种机制的参与。目前已发现三种主要机制参与吞噬细胞对凋亡细胞的识别,包括磷脂酰丝氨酸与磷脂酰丝氨酸受体,碳水化合物与凝集素样受体,血小板反应蛋白、CD36与玻连蛋白受体。
Apoptosis is generally recognized as an important mechanism for the regulation of normal tissue growth, as opposed to proliferation. Apoptotic cells are cleared in time, on the one hand to prevent the release of intracellular toxic substances, to avoid the occurrence of tissue inflammation; the other hand, can also prevent the release of nuclear material to prevent the occurrence of autoimmune diseases such as lupus erythematosus. Apoptotic cells are mainly phagocytic phagocytosis, contact and recognition is the prerequisite for phagocytosis, macrophage recognition of apoptotic cells have a variety of mechanisms involved. Three major mechanisms have been found to be involved in the recognition of apoptotic cells by phagocytes, including phosphatidylserine and phosphatidylserine receptors, carbohydrates and lectin-like receptors, thrombospondin, CD36 and vitronectin receptors.