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目的研究内毒素导致心肝肺肾脏器病理损伤和中药毒素清对其保护作用。方法以Ｄ－半乳糖和内毒素复制小鼠衰老内毒素模型，与青年小鼠和氢化可的松对照。结果内毒素可致青年小鼠心脏的血管和毛细血管扩张充血，肝脏中央静脉和肝窦内出现不同程度的淤血，肝细胞浊肿变性，肺组织间质充血及肺出血，肾间质毛细血管扩张充血和肾小管上皮细胞变性及蛋白渗出；而衰老小鼠心脏、肝脏的病理变化较青年小鼠更为严重。在心肝肺肾病理改变程度分级上，内毒素所致青年小鼠和衰老小鼠脏器损伤均明显重于青年正常和衰老模型小鼠（Ｐ＜０．０１）。毒素清和氢化可的松组的内毒素诱发脏器的病理损伤均有较明显的改善，毒素清高剂量和氢化可的松减轻心脏和肝脏损伤程度均较衰老内毒素组明显（Ｐ＜０．０１～０．０５），毒素清高低剂量和氢化可的松对肺脏病理损伤的缓解均有极显著意义（Ｐ＜０．０１）。氢化可的松虽能使肝淤血和肺的充血及出血有所改善，但可使肝细胞的点状坏死增加和间质性肺炎样病理改变加重。结论内毒素诱发衰老小鼠主要脏器的病理损伤多较青年小鼠严重，毒素清对上述的脏器损伤有明显保护作用。
Objective To study the endotoxin cause pathological damage of heart, liver, lung and kidney and toxin of traditional Chinese medicine on its protective effect. Methods The mouse model of aging endotoxin was replicated with D-galactose and endotoxin, compared with young mice and hydrocortisone. Results Endotoxin could cause vasodilation and congestion of blood vessels and capillaries in the heart of young mice. There were different degrees of congestion in the central venous and hepatic sinusoids, degeneration of hepatocytes, interstitial lung congestion and pulmonary hemorrhage, Dilatation and congestion and renal tubular epithelial cell degeneration and protein exudation; and aging mice heart, liver pathological changes more serious than the young mice. Histopathological changes in heart, liver and kidney pathological grading, endotoxin-induced young mice and senile mice organ damage were significantly heavier than the young normal and aging model mice (P <0.01). Toxin Qing and hydrocortisone groups of endotoxin-induced pathological injury organs were significantly improved, high-dose toxin and hydrocortisone reduce heart and liver damage were significantly higher than the aging endotoxin group (P <0.01 ~ 0.05). Both high and low doses of toxin and hydrocortisone had significant effects on the pathological changes of lung (P <0.01). Although hydrocortisone can make the liver congestion and lung congestion and bleeding improved, but can increase the dot-like necrosis of hepatocytes and interstitial pneumonia-like pathological changes. Conclusion The pathological damage of major organ in endotoxin-induced aging mice is more serious than that in young mice. Toxinsol can obviously protect the above organ from injury.