肺水肿是以肺部微血管通透性增高为主的微循环障碍,静脉注射肾上腺素造成大鼠致死性肺水肿模型,类似於中枢性肺水肿,具有动力性及非动力性双重机制,用山茛菪硷(654-Ⅱ)30mg/kg预防发病,效果显著,死亡率从100％降至4.4％,为探讨肺水肿发病机理中,前列腺素E_2(PGE_2)的变化以及654-Ⅱ对PGE_2的影响,本实验用放射免疫法测定了正常对照 Pulmonary edema is a microcirculation disorder characterized by increased pulmonary microvascular permeability, intravenous injection of epinephrine causes fatal pulmonary edema in rats, similar to the central pulmonary edema, with a dynamic and non-motor dual mechanism, with mountains (654-Ⅱ) 30mg / kg to prevent the onset, the effect is remarkable, the mortality rate dropped from 100% to 4.4%. To explore the pathogenesis of pulmonary edema, the changes of prostaglandin E_2 (PGE_2) and the effect of 654-Ⅱ on PGE_2 Affected, the experiment used radioimmunoassay to determine the normal control