吡噻硫酮是一个有效的抗血吸虫化合物,其作用方式尚未肯定。本文用体内和体外方法观察了药物对曼氏血吸虫的即期作用所引起的不同的生化和生理方面的变化。从感染后45～55天的小鼠体内检取曼氏血吸虫成虫,在含有0.05％戊巴比妥的培养液中分离雄虫,并移置于新鲜的培养液内,保存在37℃中备用。感染小鼠1次灌胃吡 Oltipraz is a potent anti-schistosome compound and its mode of action is not yet known. In this paper, different biochemical and physiological changes caused by the immediate effects of drugs on Schistosoma mansoni were observed in vivo and in vitro. Adults of Schistosoma mansoni were picked from mice 45 to 55 days post-infection, and the males were isolated from the culture medium containing 0.05% pentobarbital and placed in fresh culture medium and stored at 37 ° C until use . Infected mice once intragastric administration of pyridine