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实验证实二肾一夹型高血压大鼠心肌肥厚伴有左室壁羟脯氨酸浓度明显增加,并发现助阳药附子加剧这种改变,而滋阴药六味地黄方则减轻这种改变。六味地黄方降低心肌羟脯氨酸浓度,间接提示减少心肌胶原的沉着作用,这可能为该方防治心血管损害提供一定依据。由助阳药和滋阴药对该模型羟脯氨酸浓度的相反作用,可推想二肾一夹型高血压可能为中医的“阴虚”模型。
Experiments confirmed that myocardial hypertrophy in two-kidney, one-clip hypertensive rats was accompanied by a significant increase in left ventricular wall hydroxyproline concentration, and it was found that Aconite Aconite aggravated this change, and that the nourishing yin drug Liu Wei Di Huang Fang alleviated this change. Liu Wei Di Huang Fang reduced myocardial hydroxyproline concentration, indirectly prompted to reduce the role of myocardial collagen calm, which may provide some basis for the prevention and treatment of cardiovascular damage. From the opposite effect of the hydroxyproline concentration on the model by the positive and negative drugs, it can be deduced that the two-kidney-clip type hypertension may be the “yin deficiency” model of traditional Chinese medicine.