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实验大鼠分三组:损伤组给予四氯化碳(CCl_4);治疗组除给CCl_4外,用联苯双酯的吐温80混悬液灌胃共7日;对照组只给5%吐温80灌胃。结果是治疗与损伤相比,肝小叶损伤区域缩小,肝细胞中脂肪滴减少,胞质嗜硷质、硷性蛋白含量增多,SDH、G-6-P、ATP酶活性增强。对SDH和G-6-P进行显微分光光度计狭缝扫描测定,其消光值(E)在治疗组与损伤组间比较P<0.001。故认为,联苯双酯对肝损伤有修复作用,其机理可能是通过阻止内质网的损伤,促进蛋白质合成代谢所致。
The experimental rats were divided into three groups: carbon tetrachloride (CCl_4) was given to the injury group; in the treatment group, bilirubin Tween80 suspension was given to the stomach for 7 days except for CCl_4; the control group only given 5% sputum Temperature 80 gavage. As a result, compared with the treatment, the lesion area of the hepatic lobule was reduced, the fat droplets in the hepatocytes were reduced, the contents of cytoplasmic osmo-estrogen and sputum proteins increased, and the activities of SDH, G-6-P and ATPase were enhanced. SDH and G-6-P were subjected to microscopic spectrophotometer slit scanning, and the extinction value (E) was P<0.001 between the treatment group and the injury group. Therefore, it is believed that bifendate has a repairing effect on liver damage, and its mechanism may be caused by preventing the damage of the endoplasmic reticulum and promoting the anabolism of the protein.