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据记载蟾酥具有破结,行水湿、化毒、杀虫、定痛等作用(1),广泛应用于治疗恶性肿瘤、慢性骨髓炎,结核病与表面麻醉等(1、2)实验研究表明它还有强心升压与兴奋呼吸的作用,故近来有用于治疗心力衰竭、严重低血压与麻醉过深的报道(2、3)。本室证明它对实验性内毒素休克具有显著疗效。然而同位素示踪法提示蟾酥有效成分的血浆半衰期很短(8分钟左右)(2),故临床上需要较大剂量才能有效地维持治疗作川。可是历代医家都强调蟾酥“第性有毒,不宜多用”(1)。这就在一定程度上限制了它的临床应用。因此设法对抗蟾酥毒性,已成为蟾酥推广使用中一个急待解决的课题。为了探索既能充分利用蟾酥的抗休克作用,又能消除它的毒性的办法,我们观察了山茛菪硷对蟾酥毒性及其抗休克作用的影响。
According to the report, wolfberry has broken knots, and it has functions such as dampness, detoxification, insecticide, and constant pain (1). It is widely used in the treatment of malignant tumors, chronic osteomyelitis, tuberculosis and surface anesthesia, etc. (1, 2) Experimental studies have shown that There is also a strong heart boost and excitatory breathing, it has recently been used for the treatment of heart failure, severe hypotension and anesthesia (2,3). This room proved that it has a significant effect on experimental endotoxin shock. However, the isotope tracer method suggests that the plasma half-life of the active ingredient of konjac is very short (8 minutes) (2), so a larger dose is required in clinical practice to effectively maintain the therapeutic chuanchuan. However, the ancient doctors have emphasized that the Crisp is “sufficient in toxicity and should not be used more” (1). This limits its clinical application to some extent. Therefore, trying to combat the toxicity of konjac has become a pressing issue in the promotion of wolfberry. In order to explore ways to make full use of the anti-shock effect of wolfberry and to eliminate its toxicity, we observed the effects of hawthorn on the toxicity of cedar and its anti-shock effect.