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本实验应用Nonidez及Glees二种镀银法,对诱发的小鼠胶质母细胞瘤株(G 422)进行了观察。脑内及肌内接种胶质母细胞瘤后,在肿瘤边缘可见大小不等的神经束,伴随或不伴随血管伸入瘤内。有的在血管周围间隙形成血管周围神经丛。这些神经纤维与肿瘤周围宿主的脑组织、皮下、毛囊和肌肉间隙的神经纤维相联系。因此我们推测肿瘤内的神经是由肿瘤周围宿主的器官组织的神经延伸来的。肿瘤边缘的神经纤维的数量多于核心区,走行于肿瘤的间质或实质,沿途不断分支,终末分布到肿瘤细胞的表面。我们观察到球形、游离分叉状、梭形、环形、树枝状、杵状及丛刷状等类型的神经末梢。以上观察表明,恶性肿瘤——小鼠胶质母细胞瘤是受神经支配的。
In this study, Nonidez and Glees two kinds of silver plating method, the induced mouse glioblastoma strain (G 422) were observed. After intracerebral and intramuscular inoculation of glioblastoma, nerve bundles of unequal size can be seen at the margin of the tumor, with or without vascular penetration into the tumor. Some in the perivascular space to form perivascular plexus. These nerve fibers are associated with nerve fibers in the brain tissue, subcutaneous, hair follicles and muscle space of the host surrounding the tumor. Therefore, we speculate that the nerves within the tumor are extended by the nerves of the organ tissue surrounding the tumor. The number of nerve fibers on the edge of the tumor is more than that of the core region and runs along the interstitial or parenchymal tumor. Branches of the nerve fibers continue to spread to the surface of tumor cells. We observed spherical, free-forked, fusiform, circular, dendritic, clubbing, and brushlike nerve endings. The above observations show that the malignant tumor, mouse glioblastoma, is innervated.