华法令为一合成的抗凝血药物,其药效学和药动学已被广泛研究。华法令在血清或血浆中的药物浓度与抗凝效果的关系是间接和复杂的。没有食物存在时,华法令在胃和上消化道可被速迅并广泛吸收。然而,在消化道有食物存在时,华法令的吸收速率则降低。在体内和体外广泛研究了华法令同系物 Warfarin is a synthetic anticoagulant drug whose pharmacodynamics and pharmacokinetics have been extensively studied. Warfarin in the serum or plasma drug concentration and anticoagulant effect of the relationship is indirect and complex. Warfarin can be rapidly and widely absorbed in the stomach and upper digestive tract in the absence of food. However, the rate of absorption of warfarin is reduced in the presence of food in the digestive tract. Warfarin congeners have been extensively studied both in vivo and in vitro