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与位听血管疾患相关的 Cogan’s 综合征较少见,本文报告血管炎性疾患伴发耳聋、耳鸣和眩晕两例,例1,男性65岁,因风湿性多发性肌痛用小剂量皮质类固醇治疗两年,因出现耳聋、耳鸣和眩晕而逐渐撤药,以为是梅尼埃病所致,然而第4次发作时耳聋加重,呈双侧感音性聋,两个月后腿部出现了血管性疱疹性皮炎,活检证明为血管性皮肌炎;并有肾小球病损性蛋白尿,肌酐为47ml/分,血清 cANCA阳性,白细胞数为13.2×10~9/L,C_3为1.89g/L,C-反应蛋白为35ml/L,轻度酸性细胞增多。静脉内输入甲基强的松龙及口服环磷酰胺
Cogan’s syndrome associated with vascular hearing ailments is less common. This article reports two cases of vascular inflammatory conditions associated with deafness, tinnitus and vertigo. Case 1: Male 65 years old, treated with low-dose corticosteroid for rheumatic polymyalgia Two years, because of deafness, tinnitus and dizziness and gradually withdrawal, that is caused by Meniere’s disease, but the fourth attack increased deafness, bilateral sensory hearing loss, two months after the blood vessels appeared in the leg Herpes dermatitis, biopsy proved vascular dermatomyositis; and glomerular lesion proteinuria, creatinine was 47ml / min, serum cANCA positive, the number of white blood cells was 13.2 × 10 ~ 9 / L, C_3 was 1.89g / L, C-reactive protein 35ml / L, mild acidic cells increased. Intravenous methylprednisolone and oral cyclophosphamide