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氟苯哌苯醚(paroxetine)为苯基哌啶类化合物,经动物实验和人体药理、临床研究表明,该药具有高度的选择性5-羟色胺(5-HT)回收阻滞作用,其抗抑郁作用强度与三环类抗抑郁剂(TCA)相似,而副作用较TCA小。 Squires采用鼠脑神经突触实验室研究发现,本品对不同的〔~3H〕-单胺类介质回收的阻滞强度不同,其半数抑制浓度(IC_(50))分别为:前脑部位组织〔~3H〕-5-HT30nM,海马部位组织〔~3H〕-NA为250nM。Hyttel采用鼠全脑实验研究发现,本品对〔~3H〕-5-HT、〔~3H〕-NA、〔~3H〕-DA回收的IC_(50)分别为0.3
Paroxetine is a phenylpiperidine compound. In animal experiments and human pharmacology, clinical studies have shown that the drug has a highly selective 5-hydroxytryptamine (5-HT) recovery blockade and its antidepressant Intensity and tricyclic antidepressants (TCA) similar side effects and less TCA. Squires using mouse brain synapses laboratory study found that this product for different 〔~ 3H] - monoamine recovery of the different strength of the block, the median inhibitory concentration (IC 50) were: the forebrain site [~ 3H] -5-HT30nM tissue, [~ 3H] -NA in the hippocampus tissue was 250 nM. Hyttel rat whole brain experimental study found that the goods for 〔~ 3H] -5-HT, [~ 3H] -NA, [~ 3H] -DA recovery IC_ (50) were 0.3