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实验是选用纯种小白鼠进行的,共分6个周龄组;1周、2周、3周、4周、5周、6周。每组5～8只动物。每只小白鼠由腹腔注入20微居里/毫升体液的氚。小白鼠的体液因周龄不同而异。如1周的小白鼠占体重的80%,2周的为75%,3周的为70%,4、5、6周的为60%。在注入氚水后48小时杀死动物,取出肝脏作常规组织学处理,制成切片进行组织学观察。从实验结果看出;1周小白鼠的肝脏仅有轻度充血,肝细胞核变大,淋巴细胞浸润及枯否氏细胞轻度增加。2周小白鼠的肝细胞浆内有大量空泡形成,有一些肝细胞核变形及固缩,枯否氏细胞数目
The experiments were performed on purebred mice and were divided into 6 weeks of age group; 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks and 6 weeks. Each group of 5 to 8 animals. Each mouse was injected intraperitoneally with 20 micrograms per ml of body fluid of tritium. Body fluids of mice vary according to their age. For example, one week old mice account for 80% of the body weight, 75% of the two weeks, 70% of the three weeks, and 60% of the four, five and six weeks. Forty-eight hours after the injection of tritiated water, the animals were killed, the liver was taken out for routine histological treatment, and sections were made for histological observation. From the experimental results, it can be seen that the livers of mice in one week were only mildly hyperemic, the nuclei of hepatocytes became larger, the infiltration of lymphocytes and the mild increase of Kupffer cells. 2 weeks after the formation of large numbers of vacuoles in the liver cytoplasm of mice, some of the liver cell nuclear deformation and shrinkage, dry cell number