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已知疟原虫的裂殖子侵入红细胞是感染疟疾的关键.此过程必须通过对红细胞表面上特异分子的识别来进行,而红细胞的唾液糖蛋白、血型蛋白A、B及C在识别过程中极为重要。但这些分子中的什么部位起着受体的作用呢?自然,存在于血型糖蛋白N-末端的N-乙酰葡萄糖胺是首选的对象。实验证明:N-乙酰葡萄糖胺能抑制疟原虫对红细胞的侵入。这种同种分子的竞争性作用,表明N-乙酰葡萄糖胺是实际的受体。
It is known that the invasion of red blood cells by the merozoites of malaria parasites is the key to malaria infection and this process must be performed by recognizing the specific molecules on the surface of erythrocytes while the salivary glycoproteins, hemoproteins A, B and C of erythrocytes are extremely discriminating important. But what parts of these molecules act as acceptors? Naturally, N-acetylglucosamine present at the N-terminal of the glycophorin is the preferred target. Experiments show that: N-acetylglucosamine can inhibit malarial parasites on the invasion of red blood cells. The competitive effect of such allolecules suggests that N-acetylglucosamine is the actual receptor.