本文报告了45名表现为甲亢的Grave病病人用抗甲亢药物治疗,临床无症状时停药10年后的甲状腺功能和组织学改变。体格检查发现仅有2名病人有轻度甲亢,其余病人基本正常。血清甲状腺激素和TSH的测定结果证实2例FT_4I和T_3升高(6.7％),4例有T_3甲状腺中毒症(8.9％)为2例有亚临床甲低(4.4％)。其余的36人表现为生化正常。作者对这36名病人作了TRH试验,结果3例反应低下。5例反应亢进。36人中有15人接受了T_3抑制试验,其中10人受抑制,5人未被抑 This article reports the treatment of hyperthyroidism in 45 patients with Grave disease treated with anti-hyperthyroidism, thyroid function and histological changes after 10 years of clinical asymptomatic withdrawal. Physical examination found only 2 patients had mild hyperthyroidism, the rest of the patients were normal. The results of serum thyroid hormone and TSH confirmed that two patients had elevated FT_4I and T_3 (6.7%), and 4 patients had T_3 thyroidosis (8.9%), two patients had subclinical hypothyroidism (4.4%). The remaining 36 people showed normal biochemistry. The authors conducted a TRH test of these 36 patients, the results of three cases of low response. 5 cases of hyperthyroidism. Twenty-three of 36 patients underwent T_3 inhibition, of whom 10 were inhibited and 5 were not suppressed