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应用免疫荧光技术检测红斑狼疮患者皮肤活检样品的研究是1963年Burnham首先报导的,作者发现红斑狼疮患者(DLE、SLE)皮损部位的真表皮交界处有免疫球蛋白的沉积。Cormane相继证明SLE患者临床表现正常皮肤的上述部位也有这种免疫沉积物。此后Gilliam发现在NZB/NZWF_1小鼠的皮肤基底膜部位有同样的免疫沉积
The application of immunofluorescence to detect skin biopsy samples from patients with lupus erythematosus was first reported by Burnham in 1963 and the authors found immunoglobulin deposition at the dermis junction at the dermis of patients with lupus erythematosus (DLE, SLE). Cormane have successively demonstrated that these immune deposits are also found in these areas of normal skin in SLE patients. Since then Gilliam has found the same immunodeposition in the basement membrane of NZB / NZWF 1 mice