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二性霉素B对多种真菌如囊球菌、新生隐球菌、念珠菌、荚膜组织胞浆菌、粗球霉菌和皮炎芽生菌所引起的全身性和弥散性的感染都有强的抑制作用,但对细菌、立克次体和病毒的感染无效,主要用来治疗严重的、致命的真菌感染。使用二性霉素B静脉注射时,应认真检查包装,阅读说明书详细内容,而且还应懂得“如何”和“为什么”要安全使用二性霉素B。本品在应用中有十个常见的问题: 1.二性霉素B的常用注射量是多少? 本品用量不一,但常量是:第一天,试用量为1毫克,滴注2～6小时以上;第二天,为5毫克,滴注6～8小时以上;第三天起,每日或隔日增加5～10毫克直到剂量逐渐增加至0.5～1.0毫克/公斤,量大为1.5毫克/公斤,或大约50毫克。
Amphotericin B has a strong inhibitory effect on systemic and diffuse infections caused by various fungi such as Cryptococcus, Cryptococcus neoformans, Candida albicans, Histoplasma capsulatum, , But is ineffective against bacterial, rickettsial and viral infections and is primarily used to treat serious, fatal fungal infections. Use amphotericin B intravenous injection, should carefully check the packaging, read the instructions in detail, but also should understand “how” and “why” to use amphotericin B safely. The product in the application of ten common problems: 1. amphotericin B injection volume is how much? The amount of this product varies, but the constant is: the first day, try the amount of 1 mg, 2 ~ 6 hours or more; the next day, 5 mg, infusion of 6 to 8 hours or more; on the third day, daily or every other day to increase 5 to 10 mg until the dose gradually increased to 0.5 to 1.0 mg / kg, a large amount of 1.5 Mg / kg, or about 50 mg.