血管紧张素转化酶(ACE)特异性抑制剂的发展史,为酶抑制剂用作药物的研究提供了一个有普遍指导意义的样板。在研究该酶抑制剂的过程中,已经能建立若干体外和体内试验方法,这些方法对于使一个在无细胞的提取物中显示抑制作用化合物,按逻辑逐步发展而最终成为治疗人类疾病的药物是非常重要的。亦可以对该酶活性部位的性质进行考虑,设法使抑制剂与酶的相互作用达到最佳,从而发现有突出疗效和特异性的药物。一、ACE 是调节血压的一种关键性酶 The development of angiotensin-converting enzyme (ACE) -specific inhibitors has provided a universal guideline for the use of enzyme inhibitors as drugs. In the course of the study of this enzyme inhibitor, several in vitro and in vivo assays have been established that are logically progressive to eventually become drugs for the treatment of human diseases by allowing a compound that exhibits inhibitory activity in cell-free extracts very important. It is also possible to take into account the nature of the active site of the enzyme and to try to optimize the interaction of the inhibitor with the enzyme so that a drug of outstanding curative effect and specificity can be found. First, ACE is a key enzyme in regulating blood pressure