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目的评价血清中白介素-6（IL-6）检测对于早期诊断新生儿败血症的价值。方法ELISA法检测对例血培养阳性的败血症新生地急性期血清IL－6浓度，同时检测C-反应蛋白（CRP）、WBC、中性粒细胞计数（PMN）以及杆状核中性粒细胞（I）与中性粒细胞总数（T）之比，并评价各项指标的临床诊断价值。结果IL－6单独诊断时可靠性最高，其敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）、约登指数分别为85％、95％、炒叽、86％及0．80，IL-6结合CRP诊断的准确性明显优于经典的评价指标（CRP、WBC、PMN、I／T）。结论IL－6结合CRP可能是早期诊断新生儿败血症的有价值的参数。
Objective To evaluate the value of serum interleukin-6 (IL-6) in the early diagnosis of neonatal sepsis. Methods Serum levels of IL-6 in acute phase of septicemia were detected by ELISA. Serum levels of C-reactive protein (CRP), WBC, neutrophil count (PMN), and tuberculous neutrophil I) and the total number of neutrophils (T), and evaluate the clinical diagnostic value of each index. Results The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and Youden index of IL-6 were 85%, 95%, respectively .80, the diagnostic accuracy of IL-6 combined with CRP was significantly better than the classic evaluation indicators (CRP, WBC, PMN, I / T). Conclusion The combination of IL-6 and CRP may be a valuable parameter for the early diagnosis of neonatal sepsis.