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目的:探讨趋化因子受体CXCR4在胃癌中的表达及其临床意义。方法:采用免疫组织化学方法检测60例经病理检查确诊胃癌患者胃癌组织及癌旁组织CXCR4表达情况,探讨其与临床病理特征的关系。结果:胃癌组织及癌旁组织中均可检测到CXCR4的表达,胃癌组织的表达水平明显高于癌旁组织(P<0.05)。CXCR4在胃癌原发灶中的表达与肿瘤分期、分化程度及淋巴结转移相关(P<0.05),与患者年龄、性别、肿瘤部位、大小无相关性(P>0.05)。结论:胃癌组织高表达CXCR4趋化因子受体,其表达与肿瘤的分期、分化程度及淋巴结转移有关,有望成为判断胃癌预后的指标。
Objective: To investigate the expression of chemokine receptor CXCR4 in gastric carcinoma and its clinical significance. Methods: Immunohistochemistry was used to detect the expression of CXCR4 in 60 cases of gastric cancer and its adjacent tissues confirmed by pathology. The relationship between the expression of CXCR4 and clinicopathological features was analyzed. Results: The expression of CXCR4 was detected in gastric cancer tissues and adjacent tissues. The expression of CXCR4 in gastric cancer tissues was significantly higher than that in adjacent tissues (P <0.05). The expression of CXCR4 in primary gastric cancer was correlated with tumor stage, differentiation degree and lymph node metastasis (P <0.05), but not with age, sex, tumor location and size (P> 0.05). Conclusion: The expression of CXCR4 chemokine receptor in gastric cancer is highly correlated with the stage, differentiation and lymph node metastasis of gastric cancer, which is expected to be an index to judge the prognosis of gastric cancer.