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目的:探讨丙戊酸联合拉莫三嗪治疗特发性全面性癫痫的有效性和不良反应。方法:选取浙江省湖州市第一人民医院2008年2月至2014年2月收治的80例特发性全面性癫痫的患者的病例资料作为研究对象,对照组40例患者采用丙戊酸进行治疗,而观察组40例患者采用丙戊酸联合拉莫三嗪进行治疗,对比两组患者的临床疗效以及不良反应。结果:治疗后,观察组患者总有效率为97.5%,显著优于对照组患者,组间差异具有统计学意义(P<0.05),观察组患者不良反应发生率为5.0%,明显低于对照组患者,组间差异具有统计学意义(P<0.05)。结论:采用丙戊酸联合拉莫三嗪治疗特发性全面性癫痫患者具有十分显著的治疗效果,可有效改善患者的临床症状,减少发作次数,对患者的预后非常有利,值得临床推广应用。
Objective: To investigate the efficacy and adverse reactions of valproic acid combined with lamotrigine in the treatment of idiopathic generalized epilepsy. Methods: Eighty patients with idiopathic generalized epilepsy who were admitted to the First People’s Hospital of Huzhou, Zhejiang Province from February 2008 to February 2014 were selected as the study subjects, and 40 patients in the control group were treated with valproic acid , While the observation group of 40 patients treated with valproic acid combined with lamotrigine, compared the clinical efficacy and adverse reactions in both groups. Results: After treatment, the total effective rate in observation group was 97.5%, which was significantly better than that in control group (P <0.05). The incidence of adverse reactions in observation group was 5.0%, which was significantly lower than that in control group Group patients, the difference between groups was statistically significant (P <0.05). Conclusion: Valproic acid combined with lamotrigine has a very significant therapeutic effect on patients with idiopathic generalized epilepsy, which can effectively improve the clinical symptoms and reduce the number of seizures. It is very beneficial for the prognosis of patients and is worthy of clinical application.