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70年代及80年代初、中期,由于在合适的灵长类建立了疾病模型,戊型肝炎的实验室研究才有了大的进展,1983年,Balayan等人首次报道,用戊型肝炎病人的粪便提取液,经口感染一名志愿者获得成功;继而给两只猕猴静脉注射10%人大便混悬液,动物在接种后24～36小时内,血清ALT活性升高,并在发病的急性前期大便中排出27～30nm的病毒样颗粒。1989年Reyes等应用分子克隆技术获得该病毒的克隆基因,并将其命名为戊型肝炎病毒
In the mid-1970s and early 1980s, major progress was made in the laboratory study of hepatitis E due to the establishment of a disease model in the appropriate primates. In 1983, for the first time, Balayan et al reported that hepatitis E patients Faeces extract was orally infected with a volunteer success; then two macaques intravenous injection of 10% human stool suspension, animals within 24 to 36 hours after inoculation, serum ALT activity increased, and in the pathogenesis of acute Early stool discharge 27 ~ 30nm virus-like particles. 1989 Reyes and other molecular cloning technology to obtain the cloned gene of the virus, and named as hepatitis E virus