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目的 探讨东莨菪碱对急性脑缺血再灌注损伤的保护作用。方法 32例患者按顺序随机分为治疗组 (A组 )与对照组 (B组 )。A组 18例给予东莨菪碱 0 6～ 0 9mg加入 5 %GS2 5 0～ 5 0 0ml持续静滴 ,每日 <3mg ,疗程 5～ 7d。B组除不用东莨菪碱外 ,其他治疗同A组。 结果 A组治疗后显效 12例 ,有效 4例 ,无效 2例 ,总有效率 88 9%:B组有效率为 71 5 %,两组比较有显著性差异 ,P <0 0 5。结论 东莨菪碱对脑缺血再灌注损伤后脑功能的恢复有一定睥保护作用。
Objective To investigate the protective effect of scopolamine on acute cerebral ischemia-reperfusion injury. Methods 32 patients were randomly divided into treatment group (A group) and control group (B group). A group of 18 patients given scopolamine 0 6 ~ 0 9mg added 5% GS2 50 ~ 500ml continuous intravenous infusion, daily <3mg, treatment of 5 ~ 7d. In addition to scopolamine B group, other treatment with the A group. Results A group of 12 cases after treatment markedly effective in 4 cases, 2 cases were ineffective, the total effective rate of 88 9%: B group, the effective rate was 71.5%, there was a significant difference between the two groups, P <0 05. Conclusion Scopolamine has a protective effect on the recovery of brain function after cerebral ischemia-reperfusion injury.