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许多常用的心血管药物,包括盐酸普鲁卡因胺、盐酸肼苯哒嗪和苯妥英钠等,可促使抗核抗体(ANA)形成,偶尔引起一种类似全身性红斑狼疮(SLE)的综合征。但奎尼丁尚未被列入这类药物。本文报告5例奎尼丁引起的SLE. 这5例口服奎尼丁的患者,皆有SLE的临床和实验室证据。男4例,女1例,年龄50～74岁。其中2例口服硫酸奎尼丁,2例口服葡糖酸奎尼丁,1例口服奎尼丁聚半乳糖醛酸盐。服药史3～18个月。皆表现有多关节炎,血沉增快(30～93 mm/h)、ANA强阳性(1/128～1/1024)。1例发生胸膜炎伴胸
Many commonly used cardiovascular drugs, including procainamide hydrochloride, hydralazine and phenytoin, promote the formation of antinuclear antibodies (ANA) and occasionally cause a syndrome similar to systemic lupus erythematosus (SLE) . But quinidine has not been included in these drugs. This article reports 5 quinidine-induced SLE. These 5 patients with oral quinidine have both clinical and laboratory evidence of SLE. 4 males and 1 females, aged 50 to 74 years old. Two of them were given quinidine sulphate, two were given quinidine gluconate, and one was given quinidine polygalacturonate. Medication history 3 to 18 months. All showed arthritis, erythrocyte sedimentation rate (30-93 mm / h), and strong ANA (1/128 to 1/1024). 1 case of pleurisy with chest