目前有关脂质体作为抗微生物化学治疗药物载体的研究主要有以下几个方面。1.治疗内脏及皮肤利什曼病这可能是抗微生物化学治疗中应用脂质体的最好范例。在治疗利什曼病中遇到的最大问题之一就是使用含锑药物对心脏、肾脏和肝脏具有很高的毒性。脂质体包裹这些药物不仅降低了毒性而且提高了疗效。剂量可降低至八百分之一。因能使药物向肝、脾脏释放增加的缘故,而肝、脾脏是杜氏利什曼原虫感染的主要场所。Weldon John等对内脏利 The current research on liposomes as an antimicrobial chemotherapeutic drug carrier mainly includes the following aspects. 1. Treatment of visceral and cutaneous leishmaniasis This may be the best example of the use of liposomes in antimicrobial chemotherapy. One of the biggest problems in the treatment of leishmaniasis is the use of antimony-containing drugs that are highly toxic to the heart, kidneys and liver. Liposomes encapsulating these drugs not only reduces toxicity but also improves efficacy. Dose can be reduced to one hundred eighty percent. Because of the drug to the liver, spleen increased due to the increase, and liver, spleen is Leishmania donovani infection is the main place. Weldon John et al