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目的:研究适形放疗联合培美曲塞同步治疗局部晚期老年非鳞型肺癌的临床效果。方法:选取52例局部晚期非鳞型肺癌老年患者,将其随机分为观察组和对照组,对照组给予三维适形放疗治疗,观察组在此基础上给予培美曲塞同步治疗,观察比较两组的临床疗效及毒副反应发生情况。结果:观察组治疗的有效率、疾病控制率分别为61.5%、84.6%,明显高于对照组的30.8%、65.4%,P<0.05,差异具有统计学意义。两组患者毒副反应发生情况不存在明显差异,P>0.05,差异无统计学意义。结论:适形放疗联合培美曲塞同步治疗局部晚期老年非鳞型肺癌疗效肯定,不会提高毒副反应发生率,值得推广应用。
Objective: To study the clinical effect of conformal radiotherapy combined with pemetrexed in the treatment of locally advanced non-squamous lung cancer. Methods: Fifty-two elderly patients with locally advanced non-squamous lung cancer were selected and randomly divided into observation group and control group. The control group was treated with three-dimensional conformal radiotherapy. The observation group was treated with pemetrexed simultaneously. The observation and comparison Clinical efficacy and toxicity of the two groups occurred. Results: The effective rate of the treatment group and the disease control rate were 61.5% and 84.6% respectively, significantly higher than those in the control group (30.8% and 65.4%, P <0.05). The difference was statistically significant. There was no significant difference between the two groups in the incidence of side effects, P> 0.05, the difference was not statistically significant. Conclusions: Concurrent radiotherapy combined with pemetrexed is effective in treating advanced non-squamous lung cancer in the advanced stage, which will not increase the incidence of toxic and side effects and is worth popularizing and applying.