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目的探讨胎盘组织中抵抗素、脂联素及白介素-6(IL-6)的表达水平在妊娠期高血压疾病(HDCP)发生、发展中的作用,为临床诊疗提供参考。方法选取2014年3月-2015年7月在该院住院分娩的确诊为HDCP的患者55例,根据病情严重程度分为轻度子痫前期组31例和重度子痫前期组24例,另外将健康孕晚期孕妇50例作为对照组,采用免疫组化SP法对3组胎盘组织标本中的抵抗素、脂联素及IL-6表达进行检测,采用Speraman相关分析法分析各指标间的相关性。结果 3组胎盘组织中抵抗素、脂联素及IL-6的阳性率比较,差异均具有统计学意义(均P<0.05),其中抵抗素和IL-6阳性率在重度子痫前期组、轻度子痫前期组及对照组中依次降低,而脂联素则依次升高,两两比较差异均有统计学意义(均P<0.05)。HDCP患者胎盘组织中脂联素与抵抗素、IL-6分别呈明显负相关(r=-0.744,-0.597;均P<0.05),抵抗素与IL-6呈明显正相关(r=0.623;P<0.05)。结论胎盘组织中抵抗素、脂联素及IL-6表达水平与HDCP的发生及疾病的严重程度有关,且3者间存在相关性。
Objective To investigate the role of resistin, adiponectin and interleukin-6 (IL-6) in the pathogenesis and progression of HDCP in placenta and provide references for clinical diagnosis and treatment. Methods From March 2014 to July 2015, 55 patients with HDCP diagnosed as hospitalized in our hospital were divided into mild preeclampsia group (31 cases) and severe preeclampsia group (24 cases) according to the severity of the disease. In addition, Fifty healthy pregnant women in the third trimester of pregnancy were used as the control group. The expressions of resistin, adiponectin and interleukin-6 were detected by immunohistochemical SP method in three groups of placenta tissues. Speraman correlation analysis was used to analyze the correlation between the indexes . Results The positive rates of resistin, adiponectin and interleukin-6 in placenta of 3 groups were statistically significant (all P <0.05), and the positive rate of resistin and IL-6 in severe preeclampsia group, Mild preeclampsia group and control group, followed by decreased, while the adiponectin increased in turn, any difference between the two groups were statistically significant (P <0.05). There was a significant negative correlation between adiponectin and resistin and IL-6 in placental tissue of patients with HDCP (r = -0.744, -0.597; all P <0.05), and resistin positively correlated with IL-6 (r = 0.623; P <0.05). Conclusion The expression levels of resistin, adiponectin and IL-6 in placenta are related to the occurrence of HDCP and the severity of the disease, and there is a correlation between them.