目的　探讨血脂康的非调脂功能。方法　体外培养的巨噬细胞与血脂康或血脂康加甲羟戊酸 (羟甲基戊二酸单酰辅酶A还原酶产物 )孵育 ,凝胶酶谱法检测上述细胞培养基中基质金属蛋白酶 (matrixmetallopro teinases,MMPs)活性 ,WesternBlot方法鉴定MMPs类型。结果　血脂康在体外抑制巨噬细胞分泌MMP 2的活性 ,这种抑制作用呈药物浓度依赖。结论　血脂康在体外抑制巨噬细胞分泌的基质金属蛋白酶 2的活性 Objective To investigate the non-lipid-regulating function of Xuezhikang. Methods The macrophages cultured in vitro were incubated with Xuezhikang or Xuezhikang mevalonate (hydroxymethyl glutaryl coenzyme A reductase), and the activity of matrix metalloproteinase matrixmetallopro teinases, MMPs) activity, Western blot method to identify the type of MMPs. Results Xuezhikang inhibited the activity of MMP 2 secreted by macrophages in vitro. The inhibitory effect was in a drug concentration-dependent manner. Conclusion Xuezhikang inhibits the activity of matrix metalloproteinase 2 secreted by macrophages in vitro