胞浆Ca~(2+)跃升的机理和功能意义测量单细胞的胞内Ca~(2+)水平,发现许多细胞当受到刺激时产生节律性的Ca~(2+)跃升(spiking)。在心肌细胞等可兴奋性系统中,关于细胞内Ca~(2+)跃升的概念是人们熟知的,即每次心搏中心肌细胞膜的去极化可引起钙库中的钙暴发性释放。实际上,非兴奋性细胞在激素和生长因子等作用下也可发生钙库中钙的周期性释放。由于在细胞膜电压予以钳制的条件 Mechanisms and functional significance of cytoplasmic Ca ~ (2+) leapTo measure intracellular Ca ~ (2+) levels of single cells, we found that many cells produce rhythmic Ca ~ (2+) spiking when stimulated. In excitable systems such as cardiomyocytes, it is well known that the concept of intracellular Ca2 + levitation is known as the depolarization of the cardiomyocyte membrane membrane in each heartbeat that causes an outburst of calcium in the calcium pool. In fact, non-excitatory cells in the role of hormones and growth factors can also occur in the periodic calcium release calcium library. Due to the cell membrane voltage to be clamped conditions