目的研究秋水仙素（Ｃｅ）和秋水仙碱（Ｃｄ）对人外周血淋巴细胞有丝分裂效应的影响。方法应用外周血淋巴细胞培养法，分析有丝分裂指数（ＭＩ）和Ｃ有丝分裂效应。结果Ｃｅ和Ｃｄ的ＭＩ与相应对照组相比，差异有显著性（Ｐ＜００１），Ｃ有丝分裂效应Ｃｅ和Ｃｄ处理组与相应对照组之间差异亦有显著性（Ｐ＜００１）。ＭＩ和Ｃ有丝分裂效应，Ｃｄ的作用均较Ｃｅ强。并对Ｃ有丝分裂效应与非整倍体诱导活性之间的关系进行了讨论。结论Ｃ有丝分裂效应可作为化合物非整倍体诱导活性的评价指标。 Objective To study the effects of colchicine (Ce) and colchicine (Cd) on mitosis of human peripheral blood lymphocytes. Methods Peripheral blood lymphocyte culture method was used to analyze mitotic index (MI) and C-mitosis. Results There was significant difference in the MI of Ce and Cd between the control group and the corresponding control group (P <001), and there was also significant difference between the C mitosis group and the control group 01). MI and C mitosis, the role of Cd are stronger than Ce. The relationship between C-mitosis and aneuploidy inducing activity was also discussed. Conclusion C mitosis can be used as compound aneuploidy induced activity evaluation index.