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目的:探讨甲状腺激素与糖尿病类型、病情、及病程的关系。方法:选择糖尿病患者197例和健康体检者40例,采用电化学发光法测定血清甲状腺激素T3、T4、FT3、FT4、TSH,采用放射免疫法测定甲状腺激素rT3含量,观察糖尿病不同类型、病情、病程分组中T3、T4、FT3、FT4、TSH、rT3含量变化特点。结果:1型和2型糖尿病组T3、FT3、FT4均显著低于正常对照组(P分别<0.001:0.01),rT3均显著高于正常对照组(P分别<0.001:0.01):1型糖尿病组T3、.FT3、FT4、低于2型糖尿病组(P<0.05),而rT3高于2型糖尿病组(P>0.05)。HbAlc≥7%-<10%、≥10%-<13%、≥13%三组的T3、FT3和TSH低于HbAlc<70%组(P分别<0.05:0.01:0.01)。随着病程延长,T3、FT3呈降低趋势(P<0.05或0.01),rT3呈现升高趋式(P<0.05或0.01)。结论:甲状腺激素水平对糖尿病患者糖代谢的评估、病情估计、及预后有重要的临床意义。
Objective: To investigate the relationship between thyroid hormone and type of diabetes, disease and course of disease. Methods: Serum thyroid hormones T3, T4, FT3, FT4 and TSH were determined by electrochemiluminescence method in 197 diabetic patients and 40 healthy volunteers. Thyroid hormone rT3 levels were measured by radioimmunoassay. The effects of different types, Pathological changes in the group T3, T4, FT3, FT4, TSH, rT3 content changes. Results: The levels of T3, FT3 and FT4 in type 1 and type 2 diabetes mellitus group were significantly lower than those in normal control group (P <0.001 and 0.01 respectively) and rT3 were significantly higher than those in normal control group (P <0.001 and 0.01 respectively). Type 1 diabetes mellitus T3, .FT3 and FT4 were lower than those in type 2 diabetes mellitus (P <0.05), while rT3 was higher than type 2 diabetes mellitus (P> 0.05). T3, FT3 and TSH of HbAlc≥7% - <10%, ≥10% - <13%, ≥13% were lower than those of HbAlc <70% (P <0.05: 0.01: 0.01, respectively). T3 and FT3 showed a decreasing tendency (P <0.05 or 0.01) and rT3 showed a rising trend (P <0.05 or 0.01) with the prolongation of duration. Conclusion: The assessment of thyroid hormone levels in diabetic patients with glycometabolism, disease estimation and prognosis have important clinical significance.