临床药物动力学的主要任务是利用药物动力学参数解决合理用药的问题:分析临床用药方案的合理性、优选给药方案,从而指导合理用药。一个理想的给药方案要求所选用的剂量必须实用、给药间隔要切实可行、血药浓度一定要最大限度地落在治疗范围以内,使药物治疗达到安全、有效与合理的目的。四环素是临床上使用最广泛的抗生素之 The main task of clinical pharmacokinetics is the use of pharmacokinetic parameters to solve the problem of rational use of drugs: analysis of the rationality of clinical drug regimens, the preferred dosing regimen, to guide the rational use of drugs. An ideal dosing regimen requires that the dosage chosen must be practical and the dosing interval is practicable. The plasma concentration must fall within the therapeutic limits to the utmost, enabling safe, effective and rational drug treatment. Tetracycline is the most widely used antibiotic in the clinic