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在体外实验中研究了８种化疗药物作用后的个旧人肺腺癌细胞（ＧＬＣ－８２）对ＬＡＫ细胞的敏感性。ＧＬＣ－８２细胞本身对化疗药物不敏感，经药物作用２４小时后用３Ｈ－ＴｄＲ释放法检测ＬＡＫ细胞对其杀伤率。结果表明：顺铂（ＣＤＤＰ）、卡铂（Ｃａｒｂｏ）、阿霉素（ＡＤＭ）、丝裂霉素（ＭＭＣ）及长春新硷（ＶＣＲ）处理后的ＧＬＣ－８２细胞对ＬＡＫ细胞的敏感性增强；环磷酰胺（ＣＴＸ）、足叶乙甙（ＶＰ１６）及５－氟脲嘧啶（５－Ｆｕ）则无明显影响。实验提示：对化疗不敏感的肺腺癌用ＣＤＤＰ、Ｃａｒｂｏ、ＡＤＭ、ＭＭＣ及ＶＣＲ后加用ＬＡＫ细胞可提高肺癌治疗的有效率。
The sensitivity of old human lung adenocarcinoma cells (GLC-82) to LAK cells after 8 chemotherapeutic drugs was studied in vitro. GLC-82 cells were not sensitive to chemotherapeutic drugs. After 24 hours of drug treatment, 3K-TdR release method was used to detect the killing rate of LAK cells. The results showed that the sensitivities of GLC-82 cells treated with cisplatin (CDDP), Carbo, adriamycin (ADM), mitomycin (MMC) and Vincristine (VCR) to LAK cells were enhanced. ; Cyclophosphamide (CTX), Etoposide (VP16) and 5-Fluorouracil (5-Fu) had no significant effect. Experiments show that the use of LAK cells after CDDP, Carbo, ADM, MMC, and VCR in lung adenocarcinoma insensitive to chemotherapy can increase the efficiency of lung cancer treatment.