目的:胺碘酮属第三类抗心律失常药、是有效的冠状血脉扩张剂。然而,尚未获得其在人体内对血管系统扩张作 用的直接证据。本文旨在研究胺碘酮对预先收缩的人手静脉的短期效应,以揭示其潜在的机制。 方法:采用手背静脉顺应技术的作用研究31名男性健康受试者。其手静脉首先用α_1-肾上腺素能受体激动剂去氧 AIM: Amiodarone is a third class of antiarrhythmic drugs and is an effective coronary vasodilator. However, no direct evidence of its effect on the vasodilatation in the human body has been obtained. This article aims to investigate the short-term effects of amiodarone on pre-contracted human hand veins in order to reveal its underlying mechanism. METHODS: Totally 31 male healthy subjects were studied using the technique of hand dorsal vein compliance. The hand vein is first deoxygenated with an alpha-adrenergic receptor agonist