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蒽环类抗生素阿霉素和正定霉素已相当广泛的应用于抗肿瘤化学疗法中,前者用于治疗肺癌已屡见不鲜,但后者在这方面的应用却未见专题报道。本文采用了取自肺癌根治性手术患者19例(腺癌8例、扁平细胞癌10例和小细胞癌1例)的肺癌细胞异种移植物植入小鼠腹腔,分别注射阿霉素7mg/kg,正定霉素10mg/kg,以及等量渗盐水24小时后给各组动物均注射~3H-胸腺嘧啶3.7×10~4
Anthracyclines doxorubicin and daunorubicin have been widely used in anti-tumor chemotherapy, the former for the treatment of lung cancer has been common, but the latter application in this area but no special reports. In this study, lung cancer cells were implanted into the peritoneal cavity of 19 mice with adenocarcinoma (8 cases of adenocarcinoma, 10 cases of squamous cell carcinoma and 1 case of small cell carcinoma), and injected with doxorubicin 7 mg / kg , Naringin 10mg / kg, and the same amount of isotonic saline 24 hours after injection of each group of animals were injected ~ 3H-thymine 3.7 × 10 ~ 4