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目的分析2型糖尿病患者的EQ-5D结构效度,以进一步认识和应用。方法资料来自于2010年全国23个省(市)的103个临床试验中心调查资料,对象为9872例15岁及以上的口服降糖药物的2型糖尿病患者。采用验证性因子分析进行结构效度分析,并用PA-OV递归模型(Path analysis with observed variables)来探索生活质量影响因素。结果量表5个维度可以提取出2个公因子,分别命名为“主动生活质量”和“感知生活质量”。行动、平常活动和自我照顾三维度在“主动生活质量”上因子载荷分别为0.82、0.84和0.88,而疼痛、不舒服在“感知生活质量”上因子载荷分别为0.71和0.56,自我照顾存在跨因子现象。主动和感知生活质量2个初阶因子在“整体生活质量”上的因子载荷分别为0.66和0.88。一阶和二阶验证性因子分析模型适配度均较好,模型稳定。结论验证性因子分析能较好地评价EQ-5D结构效度,并能应用于2型糖尿病患者生活质量影响因素的探索。
Objective To analyze the structural validity of EQ-5D in patients with type 2 diabetes for further understanding and application. Methods Data were collected from 103 clinical trial centers in 23 provinces (municipalities) in China in 2010 for 9872 patients with type 2 diabetes who were oral glucose-lowering drugs aged 15 and over. Structural validity was analyzed using confirmatory factor analysis and factors affecting quality of life were explored using the PA-OV recursive model (Path analysis with observed variables). The results of the five dimensions can extract two common factors, named “active quality of life” and “perceived quality of life.” The three factors of action, normal activity and self-care were 0.82, 0.84 and 0.88 for active quality of life and 0.71 and 0.56 for pain and discomfort respectively, Self-care exists cross-factor phenomenon. Active and perceived quality of life The two factorial factors in the “overall quality of life” factor load of 0.66 and 0.88 respectively. The first-order and second-order confirmatory factor analysis models fit well and the model is stable. Conclusion Confirmatory factor analysis can evaluate the structural validity of EQ-5D and can be used to explore the influencing factors of quality of life in patients with type 2 diabetes mellitus.