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目的评价妊娠中期母血清生化标志物筛查唐氏综合征(21-三体综合征)的临床价值。方法1996年7月至2003年6月,南京市妇幼保健院用时间分辨荧光分析法对13175例妊娠14~20周的孕妇进行血清甲胎蛋白(AFP)、游离绒毛膜促性腺激素(free-β-HCG)检测,切割值1∶300,对高风险者行羊水检查。结果21-三体综合征及18-三体综合征的检出率为5.3/万,假阳性率为10.69%。唐氏综合征高风险组胎儿异常的发生率高于唐氏综合征低风险组(P<0.01)。≥35岁孕妇组胎儿异常的发生率高于<35岁孕妇组(P<0.05)。结论AFP、free-β-HCG可用于筛查唐氏综合征及胎儿异常。
Objective To evaluate the clinical value of biochemical markers of maternal serum in the screening of Down’s syndrome (21-trisomy syndrome) in the second trimester of pregnancy. Methods From July 1996 to June 2003, 3175 pregnant women of 14 to 20 weeks of gestation were tested for AFP, free-form chorionic gonadotropin (hCG) by using time-resolved fluorescence analysis in Nanjing MCH. β-HCG) test, the cut value of 1: 300, amniotic fluid examination of high risk persons. Results The detection rate of 21-trisomy and 18-trisomy was 5.3 per 100 000 and the false-positive rate was 10.69%. The incidence of fetal abnormalities in high-risk Down’s syndrome group was higher than in low-risk Down’s syndrome group (P <0.01). The incidence of fetal abnormalities in the group of 35-year-old pregnant women was higher than that in the group of pregnant women <35 years of age (P <0.05). Conclusion AFP and free-β-HCG can be used to screen Down’s syndrome and fetal abnormalities.