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建立了一种生物亲合超滤新方法,以解决抗癌活性物质的快速筛选问题。生物亲合超滤法的设计是以拓扑异构酶Ⅱ（TOPO Ⅱ）作为靶酶,对蒽环类的拓扑异构酶抑制剂阿霉素和柔红霉素进行筛选,并以调血脂药物普伐他汀作为对照,结合高效液相色谱和质谱技术对筛选出的物质进行快速分析,取得了较好的结果。
A new method of bioaffinity ultrafiltration was established to solve the problem of rapid screening of anti-cancer active substances. Bioaffinity ultrafiltration design is topoisomerase Ⅱ (TOPO Ⅱ) as a target enzyme anthracycline topoisomerase inhibitors doxorubicin and daunorubicin screening, and lipid-lowering drugs Pravastatin as a control, combined with high performance liquid chromatography and mass spectrometry technology for rapid screening of the selected substances, and achieved good results.