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我院自1991年10月至1992年10月,应用依那普利舌下含服治疗高血压急症30例,观察其即时降压作用,临床结果提示疗效显著,现报告如下。一、观察对象 30例高血压患者,男26例,女4例;年龄34～74 岁(平均56.3±8.4岁);高血压病史2～24年。其中难治性高血压9例,高血压合并脑血管意外9例,合并冠心病7例,合并急性左心衰2例,高血压脑病2例,高血压危象1例。二、给药方法依那普利10毫克研细置于病人舌下,嘱病人平卧位休息。用药后5min、15min、30min分别测血压,心率1次,以后每小时测量1次观察8小时,同时观察临床症状、药物反应等变化。一次用药15min后血压降低不理想者再含服10毫克。降压效果按1979年
Our hospital from October 1991 to October 1992, the application of enalapril sublingual administration of 30 cases of emergency treatment of hypertension, the observed immediate antihypertensive effect, the clinical results suggest a significant effect, are as follows. First, the observed object 30 cases of hypertensive patients, 26 males and 4 females; aged 34 to 74 years (mean 56.3 ± 8.4 years); history of hypertension for 2 to 24 years. Including refractory hypertension in 9 cases, 9 cases of hypertension with cerebrovascular accident, 7 cases of coronary heart disease, acute left heart failure in 2 cases, hypertensive encephalopathy in 2 cases, 1 case of hypertensive crisis. Second, the method of administration Enalapril 10 mg research fine placed in the patient’s tongue, instruct patient supine position to rest. Blood pressure and heart rate were measured at 5 minutes, 15 minutes and 30 minutes after treatment, respectively, and observed once every hour for 8 hours. At the same time, clinical symptoms and drug reactions were observed. A medication 15min after the blood pressure is not ideal to re-containing service 10 mg. Antihypertensive effect according to 1979