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目的:探讨雌激素治疗青春期功能性子宫出血的临床疗效情况。方法:选取2007年12月-2014年4月收治的青春期功能性子宫出血患者68例,随机分成观察组、对照组各34例,对照组给予常规治疗,观察组在常规治疗基础上给予雌激素联合治疗,对两组患者的临床疗效情况进行比较分析。结果:观察组出血控制时间、止血时间、住院时间均显著短于对照组,P<0.05,具有统计学意义。两组患者在治疗期间均未出现严重不良反应,观察组出现恶心1例,头痛1例,不良反应发生率为5.88%;对照组出现恶心1例,不良反应发生率为2.94%。观察组不良反应发生率显著高于对照组,并具有显著性差异,(x2=19.58,P<0.05),有统计学意义。结论:给予青春期功能性子宫出血患者在常规治疗基础上联合应用雌激素治疗,可以显著缩短患者的临床止血时间,提高临床疗效,并且安全性较高,值得临床推广使用。
Objective: To investigate the clinical efficacy of estrogen in treatment of adolescent dysfunctional uterine bleeding. Methods: Sixty-eight patients with functional dysfunctional uterine bleeding who were admitted from December 2007 to April 2014 were randomly divided into observation group (34 cases) and control group (34 cases). The control group was given routine treatment. The observation group was given estrogen Combined treatment, the clinical efficacy of two groups of patients were analyzed. Results: The bleeding control time, bleeding time and hospital stay in observation group were significantly shorter than those in control group (P <0.05), with statistical significance. There was no serious adverse reactions in both groups during the treatment. The observation group showed nausea in 1 case, headache in 1 case, adverse reaction rate in 5.88%, nausea in control group in 1 case and adverse reaction rate in 2.94%. The incidence of adverse reactions in the observation group was significantly higher than that in the control group, with significant difference (χ2 = 19.58, P <0.05), with statistical significance. Conclusion: The combination of estrogen therapy with puberty dysfunctional uterine bleeding can significantly shorten the patients’ clinical bleeding time and improve the clinical curative effect, and it is safe and worthy of clinical application.