【化学名】 1,3-双(2-羧基色酮-5-氧)-2-羟基丙烷二钠盐【结构式】【作用特点】本品为一新型的哮喘防治药物,其作用原理虽不完全清楚,但它对支气管平滑肌无舒张作用,而可能是抑制抗原与抗体结合所产生的中间物质,如组织胺、5-羟色胺、慢作用过敏物质(SRS-A)等的释放。本品对外源性哮喘有较好的疗效,特别是对季节性哮喘和青少年患者疗效更佳。对依赖皮质激素的哮喘病人,本品可以全部或部分取代皮质激素的治疗。本品毒性甚低,小动物胃肠道外给药LD_(50)为2～4克/公斤,排泄迅速,在任何织组中无蓄积现象。【适应症】适用于外源性哮喘,尤适用于季节性哮喘及儿童患者。【用法与用量】 1.本品仅在喷雾吸入时疗效良好,故采用特制的干粉喷雾器进行喷雾吸入给药。 2.剂量一般按每六小时给药一次,每次20毫克(一胶囊)。少数病例可能需要适当增加用药次数。 3.原用支气管扩张剂和皮质激素作维持治疗者,在用本品后仍应给予原用药物,至 【Chemical Name】 1,3-bis (2-carboxy-chromone-5-oxy) -2-hydroxypropane disodium salt 【Structure】 【Features】 This product is a new type of asthma prevention and treatment of drugs, the principle of action, though not It is well understood, but it has no effect on bronchial smooth muscle relaxation, but may inhibit the release of intermediate substances such as histamine, serotonin and slow acting allergic substance (SRS-A) produced by antigen-antibody binding. This product has a good effect on extrinsic asthma, especially for patients with seasonal asthma and adolescents better. For cortical hormone-dependent asthma patients, this product can be completely or partially replaced corticosteroid treatment. This product is very low toxicity, small animal gastrointestinal administration LD_ (50) of 2 to 4 g / kg, excretion quickly, no accumulation in any weave phenomenon. Indications for exogenous asthma, especially for seasonal asthma and children patients. Usage and Dosage 1. This product is only good effect when spray inhalation, so the use of a special dry powder spray inhalation drug delivery. 2. Dosage is generally given once every six hours, each 20 mg (a capsule). A small number of cases may need to increase the number of medication. 3. The original bronchodilators and corticosteroids for maintenance treatment, after using this product should still be given the original drug to