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药物在预定作用部位的疗效,可在合并用药或与其他药相互作用时加强或减弱,这种相互反应(Interaction)可发生在药物的吸收之前、体内转运或贮存期间,亦可发生在肝和其他组织的生物转化以及排泄过程中。本文用表列举了一些药物的已知相互反应,并概要地阐述了支配药物相互反应的一般作用原理。 1.影响药物吸收的相互反应: 除了直接注射于血循环或细胞外体液的药物以外,通常药物必须先穿透活细胞形成的屏障——如胃和小肠的粘膜,然后进入血
The efficacy of a drug at a predetermined site of action can be enhanced or attenuated upon or in conjunction with other drugs that can occur prior to the absorption of the drug, during transport or storage in the body, or in the liver and Biotransformation and excretion of other tissues. This paper lists the known interactions of some drugs with tables and outlines the general principles that govern the interaction of drugs. 1. Mutagenesis that Affects Drug Absorption: In addition to drugs that are injected directly into the bloodstream or extracellular fluid, drugs typically must first penetrate barriers formed by living cells - such as the mucous membranes of the stomach and small intestine, and then into the blood