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目的:探讨不同起始时间的超声低频脉冲治疗对骨水泥载万古霉素的药动学影响。方法:选取健康大鼠42只,将标准金黄色葡萄球菌和载万古霉素骨水泥植入大鼠髋关节部。随机将大鼠分为观察组及对照组,每组21只。观察组大鼠在植入12 h后开始超声低频脉冲治疗,对照组大鼠在植入30 min即开始超声低频脉冲治疗,比较两组药动学和药效参数。结果:观察组大鼠有效抑菌浓度持续时间比对照组长,峰值浓度与最低抑菌浓度比值低于对照组,差异均有统计学意义(P<0.05);观察组大鼠渗液菌落计数、渗血量均少于对照组,差异均有统计学意义(P<0.05)。结论:在术后12 h开始超声低频脉冲处理载万古霉素骨水泥的大鼠髋关节处可增加血药浓度,延长抗菌效能,效果更好。
OBJECTIVE: To investigate the pharmacokinetics of vancomycin-loaded bone cement with different initial time of ultrasonic low-frequency pulse therapy. Methods: Forty-two healthy rats were selected and standard Staphylococcus aureus and vancomycin-containing bone cement were implanted into the hip joint of rats. Rats were randomly divided into observation group and control group, 21 in each group. The rats in the observation group began to be treated with ultrasonic bass pulsation 12 hours after implantation. The rats in the control group started ultrasonic biliary pulse therapy 30 minutes after implantation, and the pharmacokinetic and pharmacodynamic parameters were compared between the two groups. Results: The effective inhibitory concentration in the observation group was longer than that in the control group, and the ratio of the peak concentration to the minimum inhibitory concentration was lower than that in the control group (P <0.05). The exudate colonies count , The amount of oozing was less than the control group, the difference was statistically significant (P <0.05). CONCLUSION: At the start of operation 12 h after ultrasonic low-frequency pulse treatment, vancomycin bone cement can increase blood concentration and prolong antibacterial efficacy in rats with hip joint.