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将小鼠随机分成四组,分别给予马拉硫磷0、22.19,119.07和238.14mg/kg,连续灌胃20天。观察结果:马拉硫磷119.07和238.14mg/kg组小鼠,初次免疫反应血清溶血素水平高于对照组(P<0.05),再次免疫反应低于对照组(p<0.01);外周血淋巴细胞α-醋酸萘酯酶活性,给药组明显受到抑制(P<0.01),免疫系统的改变伴随着全血胆碱酯酶活性抑制。提示免疫系统的改变可能与马拉硫磷对胆碱酯酶的抑制有关。本实验未发现马拉硫磷引起小鼠脾细胞体外转化功能和腹腔巨噬细胞吞噬功能的改变。
The mice were randomly divided into four groups, respectively, malathion 0,22.19,119.07 and 238.14mg / kg, continuous gavage for 20 days. The results showed that the level of serum hemolysin in the first immunization was higher than that in the control group (P <0.05), and the re-immunization was lower than that in the control group (p <0.01); the level of serum hemolysin in 119.07 and 238.14mg / kg malathion- Cell α-naphthyl acetate esterase activity was significantly inhibited (P <0.01), and immune system changes were accompanied by inhibition of whole blood cholinesterase activity. Suggesting that changes in the immune system may be related to malathion on the inhibition of cholinesterase. This experiment did not find malathion-induced murine spleen cell transformation in vitro and peritoneal macrophage phagocytosis.