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曲尼司特(Tranilast)是一种平喘新药。本实验测定了五名健康自愿受试者口服曲尼司特后的血药浓度。根据药物浓度一时间的数据,用微型电子计算机进行药动学模型拟合并计算其有关参数。结果表明:口服曲尼司特药动学为一室模型,它的吸收速率为0.7671h~(-1),消除速率为0.1206h~(-1),分布容积为4.60L_1,半衰期为6.41h,曲线下面积为492.4μg·h/ml。t_0=0.89h 表明它具有滞后时间。实验中使用了紫外分光光度法测定曲尼司特的血药浓度,具有快速、简便、准确的优点。
Tranilast is a new anti-asthma drug. This experiment measured the blood concentration of five healthy volunteers after oral tranilast. According to the data of drug concentration for a time, the pharmacokinetic model fitting and calculation of the relevant parameters were performed by the microcomputer. The results showed that the pharmacokinetics of oral tranilast was a one - compartment model with an absorption rate of 0.7671 h -1, a elimination rate of 0.1206 h -1, a distribution volume of 4.60 L -1 and a half - life of 6.41 h , The area under the curve was 492.4 μg · h / ml. t_0 = 0.89h indicates that it has a lag time. In the experiment, UV spectrophotometry was used to determine the plasma concentration of tranilast, which was rapid, simple and accurate.