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目的：评价９９ｍ锝一甲氧基异丁基异腈（９９ｍＴｃ－ＭＩＢＩ）ＳＰＥＣＴ显像对心肌梗塞范围的估测及硝酸甘油介入后对存活心肌检测的价值。材料和方法：７条杂种犬通过结扎冠状动脉造成心肌梗塞模型，分别在实验第一天及实验第七天行９９ｍＴｃ－ＭＩＢＩＳＰＥＣＴ静息显像及硝酸甘油介入９９ｍＴｃ－ＭＩＢＩ心肌显像。用圆周剖面法定量分析短轴６个断面心肌缺损面积大小。结果：末次显像缺损面积与病理梗塞面积有良好相关性（ｒ＝０．８６和ｒ＝０．８７分别为硝酸甘油介入前后心肌缺损面积与病理梗塞面积的相关系数），末次显像与首次显像相比缺损面积明显缩小（Ｐ＜０．０５），硝酸甘油介入后心肌显像的平均缺损面积在首次和末次显像均明显减小（Ｐ＜０．０１），且缺损区的平均计数在硝酸甘油介入后均明显增高（Ｐ＜０．０５）。结论：９９ｍＴｃ－ＭＩＢＩ心肌断层显像是了解急性心肌梗塞范围的较好手段及硝酸甘油介入９９ｍＴｃ－ＭＩＢＩＳＰＥＣＴ显像可以提高检测低灌注区残存的存活心肌。
Objective: To evaluate the range of myocardial infarction assessed by 99m Tc-99m Tc-MIBI SPECT imaging and the value of 99mTc-MIBI in the detection of viable myocardium after nitroglycerin intervention. MATERIALS AND METHODS: Seven mongrel dogs were infused with 99mTc-MIBISPECT and 99mTc-MIBI myocardial imaging on the first day of the experiment and the seventh day after the coronary artery occlusion. Quantitative analysis of 6 short axis myocardial defect area size by circular section method. Results: There was a good correlation between the area of final defect and pathological infarct size (r = 0.86 and r = 0.87, respectively, before and after nitroglycerin intervention myocardial infarction area and pathological infarct size), the final imaging with the first (P <0.05). The mean defect area of myocardium after nitroglycerin intervention was significantly decreased at the first and last imaging (P <0.01), and the mean of defect area The counts were significantly increased after nitroglycerin intervention (P <0.05). Conclusion: 99mTc-MIBI myocardial perfusion imaging is a good means to understand the range of acute myocardial infarction and nitroglycerin intervention 99mTc-MIBISPECT imaging can improve the detection of viable myocardium in the low perfusion area.